Vaccine for pancreatic cancer could serve as a promising new therapy.
At the Memorial Sloan Kettering Center for Cancer (MSK) in New York, an experimental approach to treatment for cancer with the therapeutic vaccine based on the Basic (MRNA) “is still showing the potential” in reducing the risk of the return of the disease after surgery, a statement for the public.
Results from Clinical Phase 1 testingPublished in Nature magazine, he found that the vaccine had launched an immune response in a small group of patients.
Cancer vaccine shows promising results for certain patients
This immune-cell activation lasted almost four years after treatment, according to release.
Patients who received vaccine And they showed that the response of the immune system is more likely to be left without cancer with their three -year monitoring.
The results of the Phase 1 clinical test are still showing the potential, “MSK reported in a press release. (East)
Vinod Balandran, MD, Chief Investigator of the Tribunal and Senior Author of the Study in MSK, said his optimism regarding the efficiency of this treatment.
“We discover that with RNA vaccine technology we can learn the immune system to recognize pancreatic cancerAnd this immune response could potentially last for many years, “he said.
“The ability to start a strong, long -term immune response is required for every cancer vaccine.”
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As the pancreatic cancer is “difficult to treat”, Balachandran has shared a surprise that the immune system responded to some patients.
“It encourages us to see that our approach can learn the immune system To recognize the pancreatic cancer, that the immune response is powerful and can potentially affect patients, “he said.
“The ability to start a strong, long -term immune response is required for every cancer vaccine.”
“Although the findings are promising, these vaccines are still in the early stages of testing,” Balachandran said.
The team plans for a larger study “For further testing of these therapeutic vaccine vaccines in patients with surgically removable pancreatic cancer.”
Therapeutic vaccines target the early phase of cancer, where tumors can be surgically removed and not spread. (East)
Of the 16 participants, the vaccine stimulated the immune response in half of them. Cancer vaccine is personalized for each participant to target specific proteins found in their form of illness.
Patients also received immunotherapy drug (Atezolizumab) and standard care chemotherapy after receiving surgery.
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Cancer therapeutic vaccines such as this, called autogenic cevumeran, should treat cancer instead of preventing it, training the immune system to “recognize cancer cells as a side” according to researchers.
Patients who had an immune response to the vaccine are more likely to reduce the risk of cancer with their three -year examination. (East)
The vaccine is intended for the target of early stages of cancer that has not expanded, where tumors can be surgically removed to “help delay or prevent repetition”.
Balachandran noted that this approach can be potentially applied to other cancers.
“If you can do this with pancreatic cancer, you may theoretically be able to develop therapeutic vaccines for other cancers.”
“For pancreatic cancer patients, our latest results continue to support access to the use of personalized mrna vaccines for targeting Neoantigen in the tumor of each patient,” he said.
“If you can do this with pancreatic cancer, you may theoretically be able to develop therapeutic vaccines for other cancers.”
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The pancreatic cancer remains one of the most deadly cancer, because only about 13% of patients live five years after the diagnosis, according to the MSK -U American Cancer Society.
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Common therapies Like chemotherapy, radiation and immunotherapy are “mostly ineffective” against pancreas, MSK said, making new therapies “urgently needed”.
